Publications

The BETTER-B project builds on a large body of breathlessness research previously undertaken by the international consortium of partners from the UK, Italy, Ireland, Poland, Germany, Switzerland and Australia. The publications are ordered by release date.

 

Currow DC, Chang S, Ekström M, Hutchinson A, Luckett T, Kochovska S, Hay P, Touyz S, Dal Grande E, Johnson MJ.
Health service utilisation associated with chronic breathlessness: random population sample.
ERJ Open Res. 2021 Oct 11;7(4):00415-2021. doi: 10.1183/23120541.00415-2021. PMID: 34651042; PMCID: PMC8503326.

 

Gabrielli M, Pignataro G, Candelli M, Sacco Fernandez M, Bizzarri M, Esperide A, Franceschi F; GEMELLI AGAINST COVID 2019.
Asthma in patients admitted to emergency department for COVID-19: prevalence and risk of hospitalization.
Intern Emerg Med. 2021 Oct 17. doi: 10.1007/s11739-021-02868-9. Epub ahead of print. PMID: 34657266.

 

Reedy F, Pearson M, Greenley S, Clark J, Currow DC, Bajwah S, Fallon M, Johnson MJ.
Professionals', patients' and families' views on the use of opioids for chronic breathlessness: A systematic review using the framework method and pillar process.
Palliat Med. 2021 Sep;35(8):1421-1433. doi: 10.1177/02692163211032114. Epub 2021 Jul 24. PMID: 34304624.

 

Wasilewska E, Sobierajska-Rek A, Małgorzewicz S, Soliński M, Szalewska D, Jassem E.
Is It Possible to Have Home E-Monitoring of Pulmonary Function in Our Patients with Duchenne Muscular Dystrophy in the COVID-19 Pandemic?-A One Center Pilot Study.
Int J Environ Res Public Health. 2021 Aug 26;18(17):8967. doi: 10.3390/ijerph18178967. PMID: 34501557; PMCID: PMC8430665.

 

Currow DC, Chang S, Ferreira D, Eckert DJ, Gonzalez-Chica D, Stocks N, Ekström MP.
Chronic breathlessness and sleep problems: a population-based survey.
BMJ Open. 2021 Aug 12;11(8):e046425. doi: 10.1136/bmjopen-2020-046425. PMID: 34385238; PMCID: PMC8362739.

 

Fettes L, Bayly J, de Bruin LM, Patel M, Ashford S, Higginson IJ, Maddocks M.
Relationships between prolonged physical and social isolation during the COVID-19 pandemic, reduced physical activity and disability in activities of daily living among people with advanced respiratory disease.
Chron Respir Dis. 2021 Jan-Dec;18:14799731211035822. doi: 10.1177/14799731211035822. PMID: 34382888; PMCID: PMC8370888.

 

Aronson KI, Danoff SK, Russell AM, Ryerson CJ, Suzuki A, Wijsenbeek MS, Bajwah S, Bianchi P, Corte TJ, Lee JS, Lindell KO, Maher TM, Martinez FJ, Meek PM, Raghu G, Rouland G, Rudell R, Safford MM, Sheth JS, Swigris JJ.
Patient-centered Outcomes Research in Interstitial Lung Disease: An Official American Thoracic Society Research Statement.
Am J Respir Crit Care Med. 2021 Jul 15;204(2):e3-e23. doi: 10.1164/rccm.202105-1193ST. Erratum in: Am J Respir Crit Care Med. 2021 Sep 1;204(5):616. PMID: 34283696.

 

Connellan D, Diffley K, McCabe J, Cotter A, McGinty T, Sheehan G, Ryan K, Cullen W, Lambert JS, Callaly EL, Kyne L.
Documentation of Do-Not-Attempt-Cardiopulmonary-Resuscitation orders amid the COVID-19 pandemic.
Age Ageing. 2021 Jun 28;50(4):1048-1051. doi: 10.1093/ageing/afab075. PMID: 33909020; PMCID: PMC8135469.

 

Schloesser K, Eisenmann Y, Bergmann A, Simon ST.
Development of a Brief Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness-A Delphi Survey With International Experts.
J Pain Symptom Manage. 2021 May;61(5):963-973.e1. doi: 10.1016/j.jpainsymman.2020.09.034. Epub 2020 Sep 28. PMID: 33002596.

 

Disler R, Pascoe A, Luckett T, Donesky D, Irving L, Currow DC, Smallwood N.
Barriers to Palliative Care Referral and Advance Care Planning (ACP) for Patients With COPD: A Cross-Sectional Survey of Palliative Care Nurses.
Am J Hosp Palliat Care. 2021 May 20:10499091211018192. doi: 10.1177/10499091211018192. Epub ahead of print. PMID: 34013782.

 

Poulos LM, Ampon RD, Currow DC, Marks GB, Toelle BG, Reddel HK.
Prevalence and burden of breathlessness in Australian adults: The National Breathlessness Survey-a cross-sectional web-based population survey.
Respirology. 2021 May 10. doi: 10.1111/resp.14070. Epub ahead of print. PMID: 33971059.

 

Barker RE, Brighton LJ, Maddocks M, Nolan CM, Patel S, Walsh JA, Polgar O, Wenneberg J, Kon SSC, Wedzicha JA, Man WDC, Farquhar M.
Integrating Home-Based Exercise Training with a Hospital at Home Service for Patients Hospitalised with Acute Exacerbations of COPD: Developing the Model Using Accelerated Experience-Based Co-Design.
Int J Chron Obstruct Pulmon Dis. 2021 Apr 19;16:1035-1049. doi: 10.2147/COPD.S293048. PMID: 33907391; PMCID: PMC8064617.

 

Slevin P, Kessie T, Cullen J, Butler MW, Donnelly SC, Caulfield B.
A qualitative study of clinician perceptions regarding the potential role for digital health interventions for the management of COPD.
Health Informatics J. 2021 Jan-Mar;27(1):1460458221994888. doi: 10.1177/1460458221994888. PMID: 33653189.

 

Northgraves M, Cohen J, Allgar V, Currow D, Hart S, Hird K, Hodge A, Johnson M, Mason S, Swan F, Hutchinson A.
A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE).
ERJ Open Res. 2021 Mar 29;7(1):00955-2020. doi: 10.1183/23120541.00955-2020. PMID: 33816602; PMCID: PMC8005684.

 

Kochovska S, Ferreira DH, Garcia MV, Phillips JL, Currow DC.
Perspectives on palliative oxygen for breathlessness: Systematic review and meta-synthesis.
Eur Respir J. 2021 Mar 2:2004613. doi: 10.1183/13993003.04613-2020. Epub ahead of print. PMID: 33653807.

 

Brighton LJ, Evans CJ, Farquhar M, Bristowe K, Kata A, Higman J, Ogden M, Nolan C, Yi D, Gao W, Koulopoulou M, Hasan S, Steves CJ, Man WD, Maddocks M.
Integrating Comprehensive Geriatric Assessment for people with COPD and frailty starting pulmonary rehabilitation: the Breathe Plus feasibility trial protocol.
ERJ Open Res. 2021 Mar 29;7(1):00717-2020. doi: 10.1183/23120541.00717-2020. PMID: 33816606; PMCID: PMC8005693.

 

Barker RE, Kon SS, Clarke SF, Wenneberg J, Nolan CM, Patel S, Walsh JA, Polgar O, Maddocks M, Farquhar M, Hopkinson NS, Bell D, Wedzicha JA, Man WD.
COPD discharge bundle and pulmonary rehabilitation referral and uptake following hospitalisation for acute exacerbation of COPD.
Thorax. 2021 Mar 2:thoraxjnl-2020-215464. doi: 10.1136/thoraxjnl-2020-215464. Epub ahead of print. PMID: 33653933.

 

Patel S, Palmer MD, Nolan CM, Barker RE, Walsh JA, Wynne SC, Jones SE, Shannon H, Hopkinson NS, Kon SSC, Gao W, Maddocks M, Man WD.
Supervised pulmonary rehabilitation using minimal or specialist exercise equipment in COPD: a propensity-matched analysis.
Thorax. 2021 Mar;76(3):264-271. doi: 10.1136/thoraxjnl-2020-215281. Epub 2020 Nov 1. PMID: 33132208; PMCID: PMC7892370.

 

Ekström M, Bornefalk H, Sköld CM, Janson C, Blomberg A, Sandberg J, Bornefalk-Hermansson A, Currow DC, Johnson MJ, Sundh J.
Minimal clinically important differences for Dyspnea-12 and MDP scores are similar at 2 weeks and 6 months: follow-up of a longitudinal clinical study.
Eur Respir J. 2021 Mar 25;57(3):2002823. doi: 10.1183/13993003.02823-2020. PMID: 33334935.

 

Hui D, Bohlke K, Bao T, Campbell TC, Coyne PJ, Currow DC, Gupta A, Leiser AL, Mori M, Nava S, Reinke LF, Roeland EJ, Seigel C, Walsh D, Campbell ML.
Management of Dyspnea in Advanced Cancer: ASCO Guideline.
J Clin Oncol. 2021 Apr 20;39(12):1389-1411. doi: 10.1200/JCO.20.03465. Epub 2021 Feb 22. PMID: 33617290.

 

Schunk M, Le L, Syunyaeva Z, Haberland B, Tänzler S, Mansmann U, Schwarzkopf L, Seidl H, Streitwieser S, Hofmann M, Müller T, Weiß T, Morawietz P, Rehfuess EA, Huber RM, Berger U, Bausewein C.
Effectiveness of a specialised breathlessness service for patients with advanced disease in Germany: a pragmatic fast track randomised controlled trial (BreathEase).
Eur Respir J. 2021 Feb 11:2002139. doi: 10.1183/13993003.02139-2020. Epub ahead of print. PMID: 33509957.

 

Barnes-Harris M, Allingham S, Morgan D, Ferreira D, Johnson MJ, Eagar K, Currow D.
Comparing functional decline and distress from symptoms in people with thoracic life-limiting illnesses: lung cancers and non-malignant end-stage respiratory diseases.
Thorax. 2021 Feb 16:thoraxjnl-2020-216039. doi: 10.1136/thoraxjnl-2020-216039. Epub ahead of print. PMID: 33593929.

 

Genberg J, Davies JM, Ahmadi Z, Currow D, Johnson MJ, Tanash H, Bajwah S, Ekström M.
Indications and patterns of use of benzodiazepines and opioids in severe interstitial lung disease: a population-based longitudinal study.
ERJ Open Res. 2021 Feb 1;7(1):00716-2020. doi: 10.1183/23120541.00716-2020. PMID: 33569492; PMCID: PMC7861020.

 

Bajwah S, Colquitt J, Loveman E, Bausewein C, Almond H, Oluyase A, Dzingina M, Maddocks M, Higginson IJ, Wells A.
Pharmacological and nonpharmacological interventions to improve symptom control, functional exercise capacity and quality of life in interstitial lung disease: an evidence synthesis.
ERJ Open Res. 2021 Jan 25;7(1):00107-2020. doi: 10.1183/23120541.00107-2020. PMID: 33532482; PMCID: PMC7836673.

 

Hui D, Maddocks M, Johnson MJ, Ekström M, Simon ST, Ogliari AC, Booth S, Ripamonti C;ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org.
Management of breathlessness in patients with cancer: ESMO Clinical Practice Guidelines†.
ESMO Open. 2020 Dec;5(6):e001038. doi: 10.1136/esmoopen-2020-001038. PMID: 33303485; PMCID: PMC7733213.

 

Luckett T, San Martin A, Currow DC, Johnson MJ, Barnes-Harris MM, Phillips JL.
A systematic review and meta-analysis of studies comparing burden from lung cancer and chronic obstructive pulmonary disease.
Palliat Med. 2020 Dec;34(10):1291-1304. doi: 10.1177/0269216320940153. Epub 2020 Jul 28. PMID: 32720568.

 

Akbarshahi H, Ahmadi Z, Currow DC, Sandberg J, Vandersman Z, Shanon-Honson A, Ekström M.
No gender-related bias in COPD diagnosis and treatment in Sweden: a randomised, controlled, case-based trial.
ERJ Open Res. 2020 Nov 10;6(4):00342-2020. doi: 10.1183/23120541.00342-2020. PMID: 33263044; PMCID: PMC7682677.

 

Currow DC, Chang S, Grande ED, Ferreira DH, Kochovska S, Kinchin I, Johnson MJ, Ekstrom M.
Quality of Life Changes With Duration of Chronic Breathlessness: A Random Sample of Community-Dwelling People.
J Pain Symptom Manage. 2020 Oct;60(4):818-827.e4. doi: 10.1016/j.jpainsymman.2020.05.015. Epub 2020 May 20. PMID: 32442480.

 

Currow DC, Kochovska S, Ferreira D, Johnson M.
Morphine for the symptomatic reduction of chronic breathlessness: the case for controlled release.
Curr Opin Support Palliat Care. 2020 Sep;14(3):177-181. doi: 10.1097/SPC.0000000000000520. PMID: 32740277.

 

Fettes L, Neo J, Ashford S, Higginson IJ, Maddocks M.
Trajectories of disability in activities of daily living in advanced cancer or respiratory disease: a systematic review.
Disabil Rehabil. 2020 Sep 22:1-12. doi: 10.1080/09638288.2020.1820587. Epub ahead of print. PMID: 32961067.

 

Johnson MJ, Currow DC.
Opioids for breathlessness: a narrative review.
BMJ Support Palliat Care. 2020 Sep;10(3):287-295. doi: 10.1136/bmjspcare-2020-002314. Epub 2020 Jul 3. PMID: 32620683.

 

Currow DC, Johnson MJ, Pollack A, Ferreira DH, Kochovska S, Ekström M, Harrison C.
Breathlessness and opioid prescribing in COPD in general practice: a cross-sectional, observational study.
ERJ Open Res. 2020 Jul 6;6(2):00299-2019. doi: 10.1183/23120541.00299-2019. PMID: 32775398; PMCID: PMC7402382.

 

Tanghe M, Van Den Noortgate N, Deliens L, Smets T, Onwuteaka-Philipsen B, Szczerbińska K, Finne-Soveri H, Payne S, Gambassi G, Van den Block L, Piers R.
Opioid underuse in terminal care of long-term care facility residents with pain and/or dyspnoea: A cross-sectional PACE-survey in six European countries.
Palliat Med. 2020 Jun;34(6):784-794. doi: 10.1177/0269216320910332. Epub 2020 Apr 14. PMID: 32286149.

 

Ferreira DH, Kochovska S, Honson A, Phillips JL, Currow DC.
Two faces of the same coin: a qualitative study of patients' and carers' coexistence with chronic breathlessness associated with chronic obstructive pulmonary disease (COPD).
BMC Palliat Care. 2020 May 6;19(1):64. doi: 10.1186/s12904-020-00572-7. PMID: 32375747; PMCID: PMC7203967.

 

Henson LA, Maddocks M, Evans C, Davidson M, Hicks S, Higginson IJ.
Palliative Care and the Management of Common Distressing Symptoms in Advanced Cancer: Pain, Breathlessness, Nausea and Vomiting, and Fatigue.
J Clin Oncol. 2020 Mar 20;38(9):905-914. doi: 10.1200/JCO.19.00470. Epub 2020 Feb 5. PMID: 32023162; PMCID: PMC7082153.

 

Piotrowski WJ, Bestry I, Białas AJ, Boros PW, Grzanka P, Jassem E, Jastrzębski D, Klimczak D, Langfort R, Lewandowska K, Majewski S, Martusewicz-Boros MM, Onisch K, Puścińska E, Siemińska A, Sobiecka M, Szołkowska M, Wiatr E, Wilczyński G, Ziora D, Kuś J.
Guidelines of the Polish Respiratory Society for diagnosis and treatment of idiopathic pulmonary fibrosis.
Adv Respir Med. 2020;88(1):41-93. doi: 10.5603/ARM.2020.0081. PMID: 32153010.

 

Higginson IJ, Wilcock A, Johnson MJ, Bajwah S, Lovell N, Yi D, Hart SP, Crosby V, Poad H, Currow D, Best E, Brown S; BETTER-B Feasibility Trial Group.
Randomised, double-blind, multicentre, mixed-methods, dose-escalation feasibility trial of mirtazapine for better treatment of severe breathlessness in advanced lung disease (BETTER-B feasibility).
Thorax. 2020 Feb;75(2):176-179. doi: 10.1136/thoraxjnl-2019-213879. Epub 2020 Jan 8. PMID: 31915308; PMCID: PMC7029228.

 

Kreuter M, Wuyts WA, Wijsenbeek M, Bajwah S, Maher TM, Stowasser S, Male N, Stansen W, Schoof N, Orsatti L, Swigris J.
Health-related quality of life and symptoms in patients with IPF treated with nintedanib: analyses of patient-reported outcomes from the INPULSIS® trials.
Respir Res. 2020 Jan 30;21(1):36. doi: 10.1186/s12931-020-1298-1. PMID: 32000772; PMCID: PMC6990488.

 

Currow DC, Hunt T, Louw S, Eckert D, Allcroft P, To THM, Greene A, Krajnik M, Mahler D, Ekström M.
Isolating peripheral effects of endogenous opioids in modulating exertional breathlessness in people with moderate or severe COPD: a randomised controlled trial.
ERJ Open Res. 2019 Dec 23;5(4):00153-2019. doi: 10.1183/23120541.00153-2019. PMID: 31886161; PMCID: PMC6926367.

 

Lovell N, Etkind SN, Bajwah S, Maddocks M, Higginson IJ.
To What Extent Do the NRS and CRQ Capture Change in Patients' Experience of Breathlessness in Advanced Disease? Findings From a Mixed-Methods Double-Blind Randomized Feasibility Trial.
J Pain Symptom Manage. 2019 Sep;58(3):369-381.e7. doi: 10.1016/j.jpainsymman.2019.06.004. Epub 2019 Jun 13. PMID: 31201877.

 

Slevin P, Kessie T, Cullen J, Butler MW, Donnelly SC, Caulfield B.
A qualitative study of chronic obstructive pulmonary disease patient perceptions of the barriers and facilitators to adopting digital health technology.
Digit Health. 2019 Aug 25;5:2055207619871729. doi: 10.1177/2055207619871729. PMID: 31489206; PMCID: PMC6710666.

 

Barbetta C, Allgar V, Maddocks M, Ribeiro C, Wilcock A, Currow DC, Phillips J, Johnson MJ.
Australia-modified Karnofsky Performance Scale and physical activity in COPD and lung cancer: an exploratory pooled data analysis.
BMJ Support Palliat Care. 2019 Jul 11:bmjspcare-2019-001869. doi: 10.1136/bmjspcare-2019-001869. Epub ahead of print. PMID: 31296518.

 

Swan F, Newey A, Bland M, Allgar V, Booth S, Bausewein C, Yorke J, Johnson M.
Airflow relieves chronic breathlessness in people with advanced disease: An exploratory systematic review and meta-analyses.
Palliat Med. 2019 Jun;33(6):618-633. doi: 10.1177/0269216319835393. Epub 2019 Mar 8. PMID: 30848701.

 

Schunk M, Schulze F, Bausewein C.
What Constitutes Good Health Care for Patients with Breathlessness? Perspectives of Patients, Caregivers, and Health Care Professionals.
J Palliat Med. 2019 Jun;22(6):656-662. doi: 10.1089/jpm.2018.0319. Epub 2018 Dec 27. PMID: 30589622.

 

Brożek B, Fopka-Kowalczyk M, Łabuś-Centek M, Damps-Konstańska I, Ratajska A, Jassem E, Larkin P, Krajnik M.
Dignity Therapy as an aid to coping for COPD patients at their end-of-life stage.
Adv Respir Med. 2019;87(3):135-145. doi: 10.5603/ARM.a2019.0021. Epub 2019 May 6. PMID: 31058308.

 

Brożek B, Damps-Konstańska I, Pierzchała W, Barczyk A, Currow DC, Jassem E, Krajnik M.
End-of-life care for patients with advanced lung cancer and chronic obstructive pulmonary disease: survey among Polish pulmonologists.
Pol Arch Intern Med. 2019 Apr 30;129(4):242-252. doi: 10.20452/pamw.4478. Epub 2019 Mar 5. PMID: 30833536.

 

Brighton LJ, Miller S, Farquhar M, Booth S, Yi D, Gao W, Bajwah S, Man WD, Higginson IJ, Maddocks M.
Holistic services for people with advanced disease and chronic breathlessness: a systematic review and meta-analysis.
Thorax. 2019 Mar;74(3):270-281. doi: 10.1136/thoraxjnl-2018-211589. Epub 2018 Nov 29. PubMed PMID: 30498004

 

Brighton LJ, Gao W, Farquhar M, Booth S, Bajwah S, Man WD, Reilly CC, Yi D, Higginson IJ, Maddocks M.
Predicting outcomes following holistic breathlessness services: A pooled analysis of individual patient data.
Palliat Med. 2019 Feb 15:269216319830299. doi: 10.1177/0269216319830299. [Epub ahead of print] PubMed PMID: 30764714

 

Lovell N, Wilcock A, Bajwah S, Etkind SN, Jolley CJ, Maddocks M, Higginson IJ.
Mirtazapine for chronic breathlessness? A review of mechanistic insights and therapeutic potential.
Expert Rev Respir Med. 2019 Feb;13(2):173-180. doi: 10.1080/17476348.2019.1563486. Epub 2018 Dec 30. PubMed PMID: 30596298

 

Lovell N, Etkind SN, Bajwah S, Maddocks M, Higginson IJ.
Control and Context Are Central for People With Advanced Illness Experiencing Breathlessness: A Systematic Review and Thematic Synthesis.
J Pain Symptom Manage. 2019 Jan;57(1):140-155.e2. doi: 10.1016/j.jpainsymman.2018.09.021. Epub 2018 Oct 4. Review. PubMed PMID: 30291949

 

Brighton LJ, Tunnard I, Farquhar M, Booth S, Miller S, Yi D, Bajwah S, Man WDC, Reilly CC, Ogden M, Bailey S, Ewart C, Higginson IJ, Maddocks MT.
Recommendations for services for people with living with chronic breathlessness in advanced disease: results of a transparent expert consultation Chronic Respiratory Disease.
2019 Jan-Dec;16:1479973118816448. doi: 10.1177/1479973118816448. PubMed PMID: 30789022; PubMed Central PMCID: PMC6313262

 

Bajwah S, Davies JM, Tanash H, Currow DC, Oluyase AO, Ekström M.
Safety of benzodiazepines and opioids in interstitial lung disease: a national prospective study.
Eur Respir J. 2018 Dec 6;52(6):1801278. doi: 10.1183/13993003.01278-2018. PMID: 30309973.

 

Lovell N, Bajwah S, Maddocks M, Wilcock A, Higginson IJ.
Use of mirtazapine in patients with chronic breathlessness: A case series.
Palliat Med. 2018 Oct;32(9):1518-1521. doi: 10.1177/0269216318787450. Epub 2018 Jul 20. PubMed PMID: 30028237

 

Reilly CC, Bausewein C, Garrod R, Jolley CJ, Moxham J, Higginson IJ.
Breathlessness during daily activity: The psychometric properties of the London Chest Activity of Daily Living Scale in patients with advanced disease and refractory breathlessness.
Palliat Med. 2017 Oct;31(9):868-875. doi: 10.1177/0269216316680314. Epub 2016 Dec 15. PubMed PMID: 27932629; PubMed Central PMCID: PMC5613804

 

Maddocks M, Lovell N, Booth S, Man WD, Higginson IJ.
Palliative care and management of troublesome symptoms for people with chronic obstructive pulmonary disease.
Lancet. 2017 Sep 2;390(10098):988-1002. doi: 10.1016/S0140-6736(17)32127-X. Review. PubMed PMID: 28872031

 

Dzingina MD, Reilly CC, Bausewein C, Jolley CJ, Moxham J, McCrone P, Higginson IJ, Yi D.
Variations in the cost of formal and informal health care for patients with advanced chronic disease and refractory breathlessness: A cross-sectional secondary analysis.
Palliat Med. 2017 Apr;31(4):369-377. doi: 10.1177/0269216317690994. Epub 2017 Feb 13. PubMed PMID: 28190370; PubMed Central PMCID: PMC5405827

 

Simon ST, Higginson IJ, Booth S, Harding R, Weingärtner V, Bausewein C.
Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults.
Cochrane Database Syst Rev. 2016 Oct 20;10:CD007354. Review. PubMed PMID: 27764523

 

Gysels M, Reilly CC, Jolley CJ, Pannell C, Spoorendonk F, Moxham J, Bausewein C, Higginson IJ.
Dignity Through Integrated Symptom Management: Lessons From the Breathlessness Support Service.
J Pain Symptom Manage. 2016 Oct;52(4):515-524. doi: 10.1016/j.jpainsymman.2016.04.010. Epub 2016 Sep 17. PubMed PMID: 27650009

 

Simon ST, Weingartner V, Higginson IJ, Benalia H, Gysels M, Murtagh FE, Spicer J, Linde P, Voltz R, Bausewein C.
"I Can Breathe Again!" Patients' Self-Management Strategies for Episodic Breathlessness in Advanced Disease, Derived From Qualitative Interviews.
J Pain Symptom Manage. 2016 Aug;52(2):228-34. doi: 10.1016/j.jpainsymman.2016.02.016. Epub 2016 May 21. PubMed PMID: 27220949

 

Farquhar MC, Prevost AT, McCrone P, Brafman-Price B, Bentley A, Higginson IJ, Todd CJ, Booth S.
The clinical and cost effectiveness of a Breathlessness Intervention Service for patients with advanced non-malignant disease and their informal carers: mixed findings of a mixed method randomised controlled trial.
Trials. 2016 Apr 4;17:185. doi: 10.1186/s13063-016-1304-6. PubMed PMID: 27044249; PubMed Central PMCID: PMC4820876

 

Maddocks M, Nolan CM, Man WD, Polkey MI, Hart N, Gao W, Rafferty GF, Moxham J, Higginson IJ.
Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD: a randomised double-blind, placebo-controlled trial.
Lancet Respir Med. 2016 Jan;4(1):27-36. doi: 10.1016/S2213-2600(15)00503-2. Epub 2015 Dec 15. PubMed PMID: 26701362

 

Currow DC, Abernethy AP, Allcroft P, Banzett RB, Bausewein C, Booth S, Carrieri-Kohlman V, Davidson P, Disler R, Donesky D, Dudgeon D, Ekstrom M, Farquhar M, Higginson I, Janssen D, Jensen D, Jolley C, Krajnik M, Laveneziana P, McDonald C, Maddocks M, Morelot-Panzini C, Moxham J, Mularski RA, Noble S, O'Donnell D, Parshall MB, Pattinson K, Phillips J, Ross J, Schwartzstein RM, Similowski T, Simon ST, Smith T, Wells A, Yates P, Yorke J, Johnson MJ.
The need to research refractory breathlessness.
Eur Respir J. 2016 Jan;47(1):342-3. doi: 10.1183/13993003.00653-2015. PubMed PMID: 26721965

 

van Vliet LM, Harding R, Bausewein C, Payne S, Higginson IJ; EUROIMPACT.
How should we manage information needs, family anxiety, depression, and breathlessness for those affected by advanced disease: development of a Clinical Decision Support Tool using a Delphi design.

BMC Med. 2015 Oct 13;13:263. doi: 10.1186/s12916-015-0449-6. PubMed PMID: 26464185; PubMed Central PMCID: PMC4604738

 

Hutchinson A, Booth S, Currow D, Higginson I, Johnson M.
Invisible suffering: breathlessness in and beyond the clinic--a reply.
Lancet Respir Med. 2015 Aug;3(8):e29. doi: 10.1016/S2213-2600(15)00232-5. PubMed PMID: 26282482

 

Weingärtner V, Scheve C, Gerdes V, Schwarz-Eywill M, Prenzel R, Otremba B, Mühlenbrock J, Bausewein C, Higginson IJ, Voltz R, Herich L, Simon ST; PAALiativ.
Characteristics of episodic breathlessness as reported by patients with advanced chronic obstructive pulmonary disease and lung cancer: Results of a descriptive cohort study.

Palliat Med. 2015 May;29(5):420-8. doi: 10.1177/0269216314563428. Epub 2015 Jan 29. PubMed PMID: 25634633

 

Dunger C, Higginson IJ, Gysels M, Booth S, Simon ST, Bausewein C.
Breathlessness and crises in the context of advanced illness: A comparison between COPD and lung cancer patients.
Palliat Support Care. 2015 Apr;13(2):229-37. doi: 10.1017/S147895151300120X. Epub 2014 Feb 13. PubMed PMID: 24524686

 

Higginson IJB, C.; Reilly, C. C.; Gao, W.; Gysels, M.; Dzingina, M.; McCrone, P.; Booth, S.; Jolley, C. J.; Moxham, J.
An integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness: a randomised controlled trial.
Lancet Respir Med. 2014 Dec;2(12):979-87. doi: 10.1016/S2213-2600(14)70226-7. Epub 2014 Oct 29. PubMed PMID: 25465642

 

Moens K, Higginson IJ, Harding R; EURO IMPACT.
Are there differences in the prevalence of palliative care-related problems in people living with advanced cancer and eight non-cancer conditions? A systematic review.
J Pain Symptom Manage. 2014 Oct;48(4):660-77. doi: 10.1016/j.jpainsymman.2013.11.009. Epub 2014 May 5. Review. PubMed PMID: 24801658

 

Weingaertner V, Scheve C, Gerdes V, Schwarz-Eywill M, Prenzel R, Bausewein C, Higginson IJ, Voltz R, Herich L, Simon ST; PAALiativ Project; PAALiativ Project.
Breathlessness, functional status, distress, and palliative care needs over time in patients with advanced chronic obstructive pulmonary disease or lung cancer: a cohort study.
J Pain Symptom Manage. 2014 Oct;48(4):569-81.e1. doi: 10.1016/j.jpainsymman.2013.11.011. Epub 2014 Mar 12. PubMed PMID: 24613784

 

Farquhar MC, Prevost AT, McCrone P, Brafman-Price B, Bentley A, Higginson IJ, Todd C, Booth S.
Is a specialist breathlessness service more effective and cost-effective for patients with advanced cancer and their carers than standard care? Findings of a mixed-method randomised controlled trial.
BMC Med. 2014 Oct 31;12:194. doi: 10.1186/s12916-014-0194-2. PubMed PMID: 25358424; PubMed Central PMCID: PMC4222435

 

Simon ST, Weingärtner V, Higginson IJ, Voltz R, Bausewein C.
Definition, categorization, and terminology of episodic breathlessness: consensus by an international Delphi survey.
J Pain Symptom Manage. 2014 May;47(5):828-38. doi: 10.1016/j.jpainsymman.2013.06.013. Epub 2013 Oct 2. PubMed PMID: 24095285

 

Currow DC, Higginson IJ, Johnson MJ.
Breathlessness--current and emerging mechanisms, measurement and management: a discussion from an European Association of Palliative Care workshop.
Palliat Med. 2013 Dec;27(10):932-8. doi: 10.1177/0269216313493819. Epub 2013 Jul 9. Review. PubMed PMID: 23838379

 

Weingärtner V, Bausewein C, Higginson IJ, Scheve C, Murtagh FE, Voltz R, Simon ST.
Characterizing episodic breathlessness in patients with advanced disease.
J Palliat Med. 2013 Oct;16(10):1275-9. doi: 10.1089/jpm.2013.0087. Epub 2013 Sep 20. PubMed PMID: 24053592; PubMed Central PMCID: PMC3791043.

 

Bajwah S, Ross JR, Peacock JL, Higginson IJ, Wells AU, Patel AS, Koffman J, Riley J.
Interventions to improve symptoms and quality of life of patients with fibrotic interstitial lung disease: a systematic review of the literature.
Thorax. 2013 Sep;68(9):867-79. doi: 10.1136/thoraxjnl-2012-202040. Epub 2012 Dec 1. Review. PubMed PMID: 23204065

 

Malik FA, Gysels M, Higginson IJ.
Living with breathlessness: a survey of caregivers of breathless patients with lung cancer or heart failure.
Palliat Med. 2013 Jul;27(7):647-56. doi: 10.1177/0269216313488812. Epub 2013 May 23. PubMed PMID: 23703238

 

Patel AS, Siegert RJ, Brignall K, Gordon P, Steer S, Desai SR, Maher TM, Renzoni EA, Wells AU, Higginson IJ, Birring SS.
The development and validation of the King's Brief Interstitial Lung Disease (K-BILD) health status questionnaire.
Thorax. 2012 Sep;67(9):804-10. doi: 10.1136/thoraxjnl-2012-201581. Epub 2012 May 3. PubMed PMID: 22555278

 

Bajwah S, Higginson IJ, Ross JR, Wells AU, Birring SS, Patel A, Riley J.
Specialist palliative care is more than drugs: a retrospective study of ILD patients.
Lung. 2012 Apr;190(2):215-20. doi: 10.1007/s00408-011-9355-7. Epub 2012 Jan 5. PubMed PMID: 22218887

 

Gysels MH, Higginson IJ.
The lived experience of breathlessness and its implications for care: a qualitative comparison in cancer, COPD, heart failure and MND.
BMC Palliat Care. 2011 Oct 17;10:15. doi: 10.1186/1472-684X-10-15. PubMed PMID: 22004467; PubMed Central PMCID: PMC3206451

 

Farquhar MC, Prevost AT, McCrone P, Higginson IJ, Gray J, Brafman-Kennedy B, Booth S.
Study protocol: Phase III single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease.
Trials. 2011 May 20;12:130. doi: 10.1186/1745-6215-12-130. PubMed PMID: 21599896; PubMed Central PMCID: PMC3114770

 

Bausewein C, Booth S, Gysels M, Kühnbach R, Haberland B, Higginson IJ.
Individual breathlessness trajectories do not match summary trajectories in advanced cancer and chronic obstructive pulmonary disease: results from a longitudinal study.
Palliat Med. 2010 Dec;24(8):777-86. doi: 10.1177/0269216310378785. Epub 2010 Sep 16. PubMed PMID: 20847087

 

Bausewein C, Booth S, Gysels M, Kühnbach R, Higginson IJ.
Effectiveness of a hand-held fan for breathlessness: a randomised phase II trial.
BMC Palliat Care. 2010 Oct 19;9:22. doi: 10.1186/1472-684X-9-22. PubMed PMID: 20958972; PubMed Central PMCID: PMC2974661

 

Bausewein C, Booth S, Gysels M, Kühnbach R, Haberland B, Higginson IJ.
Understanding breathlessness: cross-sectional comparison of symptom burden and palliative care needs in chronic obstructive pulmonary disease and cancer.
J Palliat Med. 2010 Sep;13(9):1109-18. doi: 10.1089/jpm.2010.0068. PubMed PMID: 20836635

 

Gysels M, Higginson IJ.
The experience of breathlessness: the social course of chronic obstructive pulmonary disease.
J Pain Symptom Manage. 2010 Mar;39(3):555-63. doi: 10.1016/j.jpainsymman.2009.08.009. PubMed PMID: 20303029

 

Solano JP, Gomes B, Higginson IJ.
A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease.
J Pain Symptom Manage. 2006 Jan;31(1):58-69. PubMed PMID: 1644248369

 

Edmonds P, Higginson I, Altmann D, Sen-Gupta G, McDonnell M.
Is the presence of dyspnea a risk factor for morbidity in cancer patients?
J Pain Symptom Manage. 2000 Jan;19(1):15-22. PubMed PMID: 10687322

 

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